Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary Targetrat liver cytosolic glutathione S-transferase activity

General description

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.Plaumann, B., et al. 1996. Oncogene 13, 1605.Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

Warning

Toxicity: Standard Handling (A)